Journal of Yeungnam Medical Science

Cephalosporin-induced encephalopathy in patients with hematologic malignancies: a significant concern: Young Seob Park, Min Kyoung Kim, Kyung Hee Lee, Sung Ae Koh, Ji Yoon Jung, Byeong Il Jang, Se-Jin Lee; J Yeungnam Med Sci. 2023;40(Suppl):S137-S141. Published online November 14, 2023; DOI: https://doi.org/10.12701/jyms.2023.00864

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Negative myoclonus associated with tramadol use: Seong Yoon Bae, Se-Jin Lee; Yeungnam Univ J Med. 2020;37(4):329-331. Published online April 23, 2020; DOI: https://doi.org/10.12701/yujm.2020.00108

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Negative myoclonus (NM) is a shock-like jerky involuntary movement caused by a sudden, brief interruption of tonic muscle contraction. NM is observed in patients diagnosed with epilepsy, metabolic encephalopathy, and drug toxicity and in patients with brain lesions. A 55-year-old man presented with NM in both his arms and neck. He has taken medications containing tramadol at a dose of 80–140 mg/day for 5 days due to common cold. He had no history of seizures. Acute lesions were not observed during magnetic resonance imaging, and abnormal findings in his laboratory tests were not noted. His NM resolved completely after the discontinuation of tramadol and the oral administration of clonazepam. Our case report suggests that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose.

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Tramadol Induced Jerks
Waiz Wasey, Imad Aziz, Sharefi Saleh, Naila Manahil, Neha Wasey
Cureus.2021;[Epub] CrossRef

Isolated hemorrhage in the cerebellar vermis with vertigo and body lateropulsion to the contralesional side: Dong Hyun Lee, Se-Jin Lee; Yeungnam Univ J Med. 2019;36(3):269-272. Published online September 9, 2019; DOI: https://doi.org/10.12701/yujm.2019.00318

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Abstract PDF: There have been several reports of patients with isolated lesions of the cerebellar vermis presenting with clinical features similar to those of peripheral vestibulopathy. We report a case of small, isolated hematoma in the cerebellar vermis in a patient who presented with vertigo, ipsilesional nystagmus, and body lateropulsion to the contralesional side without the usual signs or symptoms of cerebellar dysfunction. Although they present with symptoms that mimic those of peripheral vestibulopathy, and brain computed tomography shows no abnormality, as there may be a small, isolated hematoma or infarction in the cerebellar vermis. Thus, brain magnetic resonance imaging should be performed in elderly patients with vascular risk factors.

Negative myoclonus associated with pregabalin: Kwan-Do Park, Min-Ku Kim, Se-Jin Lee; Yeungnam Univ J Med. 2018;35(2):240-243. Published online December 31, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.2.240

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Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before the onset of NM, he commenced the intake of pregabalin at a dose of 150 mg/day for neuropathic pain. His NM resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of pregabalin. Our study suggests that pregabalin can cause NM even in patients without a history of seizures.

Citations

Citations to this article as recorded by

Movement disorders associated with antiseizure medications: A systematic review
Daniel J. Zhou, Spriha Pavuluri, Isha Snehal, Cynthia M. Schmidt, Miguel Situ-Kcomt, Olga Taraschenko
Epilepsy & Behavior.2022; 131: 108693. CrossRef
Electrophysiological characteristics and anatomical differentiation of epileptic and non-epileptic myoclonus
Mohammad Abu-Hegazy, Azza Elmoungi, Eman Eltantawi, Ahmed Esmael
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef
Pregabalin-associated movement disorders: A literature review
JamirPitton Rissardo, AnaLetícia Fornari Caprara
Brain Circulation.2020; 6(2): 96. CrossRef
Negative myoclonus associated with tramadol use
Seong Yoon Bae, Se-Jin Lee
Yeungnam University Journal of Medicine.2020; 37(4): 329. CrossRef

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